Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{180482,
        author = {S.D. Paralkar and B.D.Tiwari and Y.S.Thorat and Ms.Sakshi Bhosale and Ms.Priyanka Dhavare},
        title = {Study of Novel Drug Delivery Approaches With Special Emphasis on Cocrystallization},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {1},
        pages = {2482-2491},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=180482},
        abstract = {Co-crystallization is an effective technique for improving the physicochemical properties of poorly soluble drugs, offering a promising solution for enhancing their bioavailability. In this study, we investigated the co-crystallization of Ziprasidone, an antipsychotic drug with limited aqueous solubility, to address its low oral absorption and therapeutic performance. By selecting a range of pharmaceutically acceptable coformers with functional groups capable of forming strong intermolecular interactions, we aimed to optimize the solubility, dissolution rate, and thermal stability of Ziprasidone. The co-crystals were prepared using solvent evaporation techniques and characterized through X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) to confirm structural formation and molecular interaction between Ziprasidone and the coformers. Experimental results demonstrated that the co-crystallized forms of Ziprasidone showed significantly improved solubility and dissolution behavior, along with enhanced thermal stability, compared to the pure API. These findings confirm that co-crystallization can effectively modify the solid-state properties of Ziprasidone, improving its pharmacokinetic profile without changing its molecular structure. Overall, this study establishes co-crystallization as a viable and scalable strategy for enhancing the delivery and therapeutic efficacy of poorly soluble drugs like Ziprasidone.},
        keywords = {Co-crystals, ziprasidone, Co-crystallization, Solubility.},
        month = {June},
        }