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@article{181059,
        author = {Krushna Raghu Bharwad and Siddhesh tarak deore and Shraddha Ambadas Navale and Shruti Deepak Borade and Khadija Yunus Shaikh and Kale Akanksha Vikas},
        title = {A SHORT OVERVIEW OF DRUG-DRUG INTERACTION},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {1},
        pages = {3242-3251},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=181059},
        abstract = {Drug-drug interactions (DDIs) constitute a major cause of medication errors in developed countries, particularly among elderly populations who frequently engage in concurrent medication use, resulting in a 20-40% prevalence rate. Therapeutic management becomes increasingly complex with poly-therapy, heightening the probability of clinically relevant DDIs that may either induce adverse drug reactions or reduce therapeutic effectiveness. DDIs are generally classified into two primary categories: pharmacokinetic and pharmacodynamic interactions.Medicinal substance interactions may result in severe adverse outcomes or diminish therapeutic efficacy. The risk increases considerably with polypharmacy, a practice particularly prevalent among geriatric populations.
The clinical manifestations of drug-drug interactions (DDIs) are extensive, potentially resulting in diminished treatment efficacy or adverse interactions that may necessitate hospitalization. For enhanced identification and prediction of DDIs, researchers employ various experimental models, computational prediction systems, and pharmacogenomic analyses. Healthcare practitioners serve a crucial function in DDI management and prevention through medication reconciliation, patient education, and therapeutic regimen modifications. Additionally, contemporary technological advancements including electronic health records and DDI warning mechanisms have contributed significantly to DDI management.},
        keywords = {Absorption, Distribution, Drug, Drug-Drug Interection, Elimination, Effect, Efficacy, Pharmacokinetics, Pharmacodynamic, Safety,},
        month = {June},
        }