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@article{181476,
        author = {Shubham thakur and Shweta Sao},
        title = {Exopolysaccharides from Probiotic Bacteria : Health Benefits and Therapeutic Potential},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {1},
        pages = {4599-4610},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=181476},
        abstract = {Exopolysaccharides (EPS) properties. These high-molecular-weight carbohydrate polymers are se-creted extracellularly by various strains of Lactobacil-lus, Bifidobacterium, Streptococcus, and other probiotic genera. While traditionally recognized for their role in biofilm formation and bacterial adhesion, recent ad-vances in microbiology, immunology, and functional food sciences have highlighted their profound impact on human health. This review aims to provide a compre-hensive overview of the structural diversity, biosynthe-sis, and functional roles of EPS derived from probiotic bacteria, with a particular focus on their therapeutic applications. EPS from probiotics exhibit diverse bio-logical activities, including immunomodulation, antiox-idative effects, antimicrobial action, cholesterol-lower-ing potential, and anti-cancer properties. These bioac-tivities are mediated through multiple mechanisms, such as modulation of immune cell signaling, inhibition of pathogenic adhesion, scavenging of reactive oxygen species, and alteration of host-microbiota interactions. Moreover, EPS contribute to gut health by enhancing mucosal barrier function and serving as prebiotic sub-strates for beneficial microbes. Their applications ex-tend beyond traditional health benefits, finding rele-vance in the development of functional foods, drug de-livery systems, and nutraceuticals. Despite their prom-ising bioactivities, challenges such as low production yield, strain variability, and limited clinical validation remain barriers to large-scale application. This review also explores emerging research avenues including syn-thetic biology approaches for enhanced EPS production and targeted delivery systems. Overall, probiotic-de-rived EPS hold immense promise as natural, safe, and effective agents for improving human health and war-rant further investigation for clinical and industrial ex-ploitation.},
        keywords = {Probiotic exopolysaccharides, Immunomod-ulation, Gut Microbiota, Antioxidant & Antimicrobial activity, Therapeutic application.},
        month = {June},
        }