Design and Biological Assessment of a Novel Thiadiazol-Imidazole Based bimetallic complex with Antimicrobial and Anti-Inflammatory Potential

  • Unique Paper ID: 182234
  • Volume: 12
  • Issue: 2
  • PageNo: 1292-1303
  • Abstract:
  • A bimetallic complex was synthesized using a novel reagent, compound-A, derived from azole compound methyl imidazole and [N{3-(5-amino-2-thione-1,3,4-thiadiazole)}]. The synthetic pathway involved a condensation reaction between [N{3-(5-amino-2-thione-1,3,4-thiadiazole)}-methyl imidazole] and a substituted triazine carboxamide derivative, resulting in the formation of compound-A. This novel reagent was then used to form a bimetallic complex through coordination with copper metal under appropriate stoichiometric conditions. The structures of both Compound-A and its bimetallic complex were characterized using UV, IR, EDS, SEM, and NMR techniques. Preliminary biological evaluations revealed that the compound exhibits significant antimicrobial (both antibacterial and antifungal) as well as anti-inflammatory activities.

Copyright & License

Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{182234,
        author = {Pooja Vilas Shinde and Dr. Willy Shah and Dr. Suhas Janwadkar},
        title = {Design and Biological Assessment of a Novel Thiadiazol-Imidazole Based bimetallic complex with Antimicrobial and Anti-Inflammatory Potential},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {1292-1303},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182234},
        abstract = {A bimetallic complex was synthesized using a novel reagent, compound-A, derived from azole compound methyl imidazole and [N{3-(5-amino-2-thione-1,3,4-thiadiazole)}]. The synthetic pathway involved a condensation reaction between [N{3-(5-amino-2-thione-1,3,4-thiadiazole)}-methyl imidazole] and a substituted triazine carboxamide derivative, resulting in the formation of compound-A. This novel reagent was then used to form a bimetallic complex through coordination with copper metal under appropriate stoichiometric conditions. The structures of both Compound-A and its bimetallic complex were characterized using UV, IR, EDS, SEM, and NMR techniques. Preliminary biological evaluations revealed that the compound exhibits significant antimicrobial (both antibacterial and antifungal) as well as anti-inflammatory activities.},
        keywords = {Bimetallic complex, Thiadiazole derivative, Methyl imidazole, Coordination chemistry, antimicrobial activity, Anti-inflammatory agent},
        month = {July},
        }

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