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@article{182373,
        author = {Aranya Ghosh and Gouri Karan and Sounik Manna and Sujata Maiti Choudhury},
        title = {Noscapine, an opium alkaloid, acts as a budding therapeutic agent for various disease conditions: A systematic review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {1637-1646},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182373},
        abstract = {Noscapine, a naturally occurring alkaloid obtained from opium poppies, has been used as an antitussive since the 1950s. Euphoria and addiction are not its effects. Several studies have demonstrated that noscapine has strong anti-inflammatory properties. It boosts antioxidant defences by lowering reactive oxygen species and nitric oxide metabolites and raising glutathione levels. Noscapine has been shown in recent research to possess antiviral properties that effectively stop the spread of viruses like human rhinovirus, respiratory syncytial virus, and some influenza strains. Additionally, noscapine's immunomodulatory properties have been demonstrated, indicating that it might be useful in managing viral infection. Research indicates that noscapine has strong antimalarial properties because it inhibits FP2, a protein essential to the malaria parasite's survival. This disruption prevents the parasite from breaking down heme, which ultimately leads to toxic accumulation and death. Noscapine has the potential to cure cerebral stroke and ischemic damage because it decreases the overexpression of bradykinin B1 and B2 receptors, which in turn reduces vascular permeability and nerve damage. Additionally, it promotes reperfusion at the site of ischemia, suggesting possible therapeutic benefits. In summary, noscapine is a flexible and diverse drug with a wide range of therapeutic uses. This study aims to provide insights into this treatment approach and to illuminate possible mechanisms via which noscapine combats different disorders.},
        keywords = {Noscapine, Pharmacokinetics; Antitussive; Antiviral; Antimalarial.},
        month = {July},
        }