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@article{182438,
        author = {Ms. Dhanashree G.Bhosale and Ms. Shubhangi L.Shete},
        title = {Formulation and Development of Nanoparticulate Tablet of Mesalamine},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {2368-2381},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182438},
        abstract = {The present study focuses on the formulation and development of nanoparticulate tablets of Mesalamine to enhance its therapeutic efficacy and patient compliance in the treatment of ulcerative colitis and Crohn’s disease. Mesalamine-loaded chitosan nanoparticles were prepared using the ionotropic gelation technique, optimizing particle size, zeta potential, and entrapment efficiency. The nanoparticles exhibited a mean particle size of 34.2 nm, polydispersibility index (PDI) of 0.534, zeta potential of +28 mV, and entrapment efficiency of 84%, indicating a stable and effective delivery system. The nanoparticulate tablets were formulated with varying ratios of Eudragit RS and Eudragit L as release-controlling polymers and evaluated for pre-compression and post-compression parameters. Results showed excellent flow properties, acceptable hardness, weight variation, friability, and disintegration times within pharmacopeial limits. In-vitro dissolution studies demonstrated sustained drug release over 60 minutes, with formulation F2 showing the most favorable release profile and stability over a 3-month period. The study concludes that the chitosan-based nanoparticulate system is a promising approach for controlled delivery of Mesalamine, improving its bioavailability and reducing gastrointestinal side effects.},
        keywords = {Mesalamine, Nanoparticles, Chitosan, Ionotropic Gelation, Nanoparticulate Tablet, Controlled Drug Delivery, Sustained Release, Bioavailability, Eudragit, Ulcerative Colitis.},
        month = {July},
        }