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@article{182774,
        author = {Rani Sanjay Nandre and Prof. Aditi Jyotishi and Dr.Karna B. khavane},
        title = {Integrative analysis of Geodorum Densiflorum Bulbs in diabetes management: network pharmacology and in vivo validation},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {3807-3837},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182774},
        abstract = {Objectives: This study aims to investigate the antidiabetic potential of Geodorum densiflorum bulbs using an integrative approach combining network pharmacology and in vivo validation.  Evaluating the glucose-lowering effects and pancreatic beta-cell function of Geodorum densiflorum bulb extracts in diabetic rat models
Method: Plant: Geodorum densiflorum  
Part- Bulb 
Extract- Hydroalcoholic Extract
Animal Model: - Alloxan Induced Hypoglycemic Model
1.. Preparation of extract: Collection, authentication, cleaned and dried. Extraction- dried bulb powder was subjected to maceration in a hydroalcoholic solution 
2. Network Pharmacology Analysis: Identifying bioactive compounds in Geodorum densiflorum bulbs and predicting their potential targets in diabetes pathways.
3. In Vivo Validation: Using Alloxan Induced Hypoglycemic Model to evaluate the glucose-lowering effects and pancreatic beta-cell function of Geodorum densiflorum bulb extracts.
Results: The network pharmacology analysis predicted key bioactive compounds, including flavonoids and phenolic compounds, and their potential targets in diabetes pathways. In vivo validation demonstrated significant glucose-lowering effects, improved insulin sensitivity, and enhanced pancreatic beta-cell function in diabetic rats treated with Geodorum densiflorum bulb extracts.
Conclusion: This study suggests that Geodorum densiflorum bulbs may be a promising natural remedy for diabetes management, warranting further research into its therapeutic potential. The integrative approach used in this study provides a comprehensive understanding of the antidiabetic effects of Geodorum densiflorum bulbs and identifies potential therapeutic targets for diabetes treatment},
        keywords = {Geodorum densiflorum, Diabetes management, Network pharmacology, In vivo validation, Antidiabetic effects, Insulin sensitivity, pancreatic beta-cell function, Therapeutic potential, Diabetes treatment},
        month = {July},
        }