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@article{182881,
        author = {Anant Rajendra Vedpathak and Shrikant S Magdum and Namrata Kengar and Tejas Patil and Vivek Koshti},
        title = {Meclizine hydrochloride lozenges:-Design, development and Characterization},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {3595-3604},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182881},
        abstract = {Background:  Meclizine hydrochloride, an antihistamine is widely utilized to alleviate vertigo, nausea, and vomiting. However, patients may find its traditional tablet shape bothersome, especially if they have difficulty in swallowing it.
Method: Meclizine hydrochloride lozenges were developed with a blend of excipients, such as binding agents, flavourings, and sweeteners by heating and congealing method. A randomized 32 full factorial design with two components and three levels was used to optimize the formulation of the lozenges. Sucrose and HPMC-E5 were independent variables and hardness and disintegration time (minute) were response variables. Formulation was assessed for thickness, diameter, hardness, weight variation, cooling, drug content, in vitro dissolution, FTIR, PXRD, DSC and stability study. 
Results: All developed lozenges were elongated, red in colour, and had good physical facets, encompassing a smooth surface. Hardness was found to be in the range of 7kg/cm2 and 16 Kg/cm2. There were no cracks, bubbles, or black specs in developed formulation. Rate of erosion of prepared lozenges ranged from 15 to 20 min. Weight variation was 1335.9 ± 0.002 mg to 2332 ± 0.001mg. Dissolution of developed lozenges (F1 -F9) was in range of 88 to 97%. 
Conclusion: Lozenges of meclizine hydrochloride were satisfactorily developed and assessed as a novel oral delivery system that served as a substitute for traditional tablets that may avert ease in swallowing since they have their high release of drugs and acceptable physical attributes.},
        keywords = {lozenges, meclizine hydrochloride, nausea, oral delivery system, patient compliance, vertigo. vomiting.},
        month = {July},
        }