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@article{182960,
        author = {Chakradhar Dubey},
        title = {Dhatu Parinama and Tissue Nutrition: Correlating Ayurvedic Metabolism with Cellular Physiology},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {4180-4186},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182960},
        abstract = {Ayurveda, the classical medical system of India, offers a unique systemic model for understanding metabolism and tissue nourishment through the concept of Dhatu Parinama—the sequential transformation of body tissues. According to this model, nutrients derived from digested food (Ahara Rasa) undergo progressive refinement via tissue-specific metabolic fires (Dhatvagni) to form the seven dhatus: Rasa (plasma), Rakta (blood), Mamsa (muscle), Meda (fat), Asthi (bone), Majja (marrow/nervous tissue), and Shukra (reproductive elements). This model presents a temporally ordered, qualitative, and adaptive framework for tissue nutrition and systemic integrity. In contrast, modern physiology explains tissue development and cellular nutrition through biochemical and molecular mechanisms—absorption, circulation, enzymatic activity, signal transduction, and nutrient prioritization—regulated by pathways such as mTOR, AMPK, and endocrine feedback loops. Although methodologically distinct, both systems emphasize the importance of digestion, metabolic sequencing, and tissue specificity in maintaining health and preventing disease. This review explores conceptual bridges between Ayurvedic metabolism and modern cellular physiology, highlighting parallels in structure, function, regulatory control, and pathological implications. We examine how the principles of Dhatu Parinama correlate with tissue turnover rates, metabolic allocation, and nutrient-driven differentiation, offering a comparative matrix for translational dialogue. Additionally, we discuss disease conditions like anemia, obesity, and infertility in both frameworks to underscore the clinical relevance of this integration. By aligning traditional Ayurvedic insight with contemporary biomedical knowledge, the article advocates for a holistic, interdisciplinary understanding of human metabolism—one that can inform personalized nutrition, regenerative medicine, and systems biology. The Dhatu Parinama framework, when viewed through the lens of physiology, emerges not as an antiquated theory but as a sophisticated metabolic model deserving deeper exploration and application in modern integrative healthcare.},
        keywords = {Dhatu Parinama; Tissue Nutrition; Ayurvedic Physiology; Cellular Metabolism; Dhatvagni; Saptadhatu; Integrative Medicine; Nutrient Transformation.},
        month = {July},
        }