Plasma Interaction with Proteins and Lipids – Investigating Structural Changes in Biomolecules Due to Plasma Exposure

  • Unique Paper ID: 183056
  • PageNo: 202-222
  • Abstract:
  • Cold Atmospheric Plasma (CAP) has gained significant attention as a versatile and non-thermal technology in biomedical science due to its rich composition of reactive oxygen and nitrogen species (ROS/RNS), charged particles, UV photons, and electric fields. One of the most intriguing aspects of CAP is its interaction with biomolecules, particularly proteins and lipids that form the structural and functional backbone of living cells. These interactions can lead to a range of structural and chemical modifications, such as oxidation, crosslinking, unfolding, fragmentation, and lipid peroxidation. Such changes have profound implications for membrane integrity, cellular signaling, and metabolic activity. Spectroscopic techniques like FTIR and circular dichroism, along with electron microscopy and molecular dynamics simulations, have helped unravel these plasma-induced alterations at molecular resolution. Understanding these mechanisms not only enhances the potential of CAP in medical therapies like cancer treatment and wound healing, but also supports its use in areas such as food safety, sterilization, and biomaterials engineering.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{183056,
        author = {Punit Kumar},
        title = {Plasma Interaction with Proteins and Lipids – Investigating Structural Changes in Biomolecules Due to Plasma Exposure},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {3},
        pages = {202-222},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=183056},
        abstract = {Cold Atmospheric Plasma (CAP) has gained significant attention as a versatile and non-thermal technology in biomedical science due to its rich composition of reactive oxygen and nitrogen species (ROS/RNS), charged particles, UV photons, and electric fields. One of the most intriguing aspects of CAP is its interaction with biomolecules, particularly proteins and lipids that form the structural and functional backbone of living cells. These interactions can lead to a range of structural and chemical modifications, such as oxidation, crosslinking, unfolding, fragmentation, and lipid peroxidation. Such changes have profound implications for membrane integrity, cellular signaling, and metabolic activity. Spectroscopic techniques like FTIR and circular dichroism, along with electron microscopy and molecular dynamics simulations, have helped unravel these plasma-induced alterations at molecular resolution. Understanding these mechanisms not only enhances the potential of CAP in medical therapies like cancer treatment and wound healing, but also supports its use in areas such as food safety, sterilization, and biomaterials engineering.},
        keywords = {Cold Atmospheric Plasma (CAP), Protein Oxidation, Lipid Peroxidation, Reactive Oxygen and Nitrogen Species (ROS/RNS), Biomolecular Structural Modification, Plasma-Biomolecule Interaction},
        month = {July},
        }

Cite This Article

Kumar, P. (2025). Plasma Interaction with Proteins and Lipids – Investigating Structural Changes in Biomolecules Due to Plasma Exposure. International Journal of Innovative Research in Technology (IJIRT), 12(3), 202–222.

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