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@article{183245,
        author = {Meka Sai Lahari and Likhitha Padavala and Srinivas Guntupalli},
        title = {“ASSESSMENT OF MEAN PLATELET VOLUME IN ACUTE ISCHEMIC STROKE AND ITS CORRELATION WITH SEVERITY OF STROKE IN OUR HOSPITAL”},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {3},
        pages = {1083-1085},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=183245},
        abstract = {Introduction:Acute ischemic stroke is a leading global cause of mortality and disability, with platelets playing a critical role in its pathophysiology. Mean Platelet Volume (MPV), a measure of platelet size and activity, is known to increase during ischemic events. This study aimed to analyse MPV in acute ischemic stroke patients and correlate it with the stroke prognosis and severity. 
Methods:
Conducted as a 12-month hospital-based observational study, the research included 96 patients over 40 years with first-episode acute ischemic stroke, confirmed by imaging. Patients with hemorrhagic stroke or prior anti-platelet medication were excluded. Key measurements included MPV and Modified Rankin Scale (MRS) scores.
Results:
Results from 96 patients showed a significant association between elevated MPV and increased stroke severity. Mean MPV increased from 8.92 ± 1.81 fL for MRS 2 to 12.10 ± 2.08 fL for MRS 4 (p=0.001). Notably, MPV showed no significant correlation with common comorbidities (diabetes, hypertension, dyslipidemia) or various pharmacological agents (aspirin, clopidogrel, statins, ACE inhibitors, anticoagulants). Furthermore, MPV significantly decreased from 11.12 ± 5.3 fL at admission to 6.5 ± 2.1 fL after one month of medication usage (p=0.001*).
Conclusion:
In conclusion, MPV serves as a significant and independent indicator of acute ischemic stroke severity and prognosis. Its responsiveness to therapeutic interventions and cost-effectiveness suggests its potential for integration into clinical practice for early risk stratification and management, though further research is warranted for comprehensive understanding and personalized care.},
        keywords = {},
        month = {August},
        }