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@article{184010,
        author = {Megha K Patel},
        title = {Formulation and Evaluation of taste masked Dry Syrup Containing Tedizolid},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {9},
        number = {11},
        pages = {1236-1241},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=184010},
        abstract = {993Oral routes of drug administration have wide acceptance up to 50-60% of total dosage forms. Many active pharmaceutical ingredients taste bitter and thus are not favoured by children, as well as many adults leading to non-adherence in many cases. Background: An attempt was made to develop a palatable reconstitutable dry syrup formulation of Tedizolid using ion exchange resin technology for effective taste masking while maintaining optimal therapeutic efficacy. Methods: Drug-resin complexes were prepared using the batch method with various ion exchange resins. Formulations were evaluated for taste masking efficiency, physicochemical properties, drug content uniformity, viscosity, sedimentation rate, redispersibility, and in vitro drug release characteristics. Accelerated stability studies were conducted to determine shelf life. Results: Indion214 resin demonstrated superior drug loading capacity of 83.87% among tested resins. The optimized formulation containing 3% guar gum as a suspending agent exhibited excellent taste masking properties, satisfactory viscosity (350-450 cPs), optimal sedimentation volume (0.85-0.95), complete redispersibility (<15 strokes), and high drug content uniformity (98.5-101.2%). In vitro drug release showed >85% within 45 minutes in gastric pH. Conclusion: The developed Tedizolid dry syrup successfully addressed the taste challenge while maintaining desirable physicochemical and release characteristics, making it a promising formulation for paediatric use.},
        keywords = {Dry syrup, Ion exchange resin, Taste masking, Tedizolid,},
        month = {August},
        }