Analytical method development and validation of capecitabine in bulk dosage form by using uv spectrophotometry

  • Unique Paper ID: 184175
  • PageNo: 1009-1022
  • Abstract:
  • A robust UV-visible spectroscopic method was developed and validated for the quantification of Capecitabine in bulk dosage form. The method is based on the drug's ultraviolet absorbance, optimized at a maximum wavelength of 325 nm. Using ethanol as the solvent, the method demonstrated linearity within the concentration range of 5–25 µg/ml, adhering to Beer's law. Validation of the method encompassed parameters such as accuracy, precision, specificity, and linearity, ensuring its reliability for pharmaceutical analysis. Recovery studies further affirmed the accuracy and applicability of the technique for routine quality control. The simplicity, rapidity, and cost-effectiveness of this UV-visible spectroscopic method make it an efficient tool for analyzing Capecitabine in bulk pharmaceutical formulations

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{184175,
        author = {B. Akhila and Patil Keerthi and N. Navya sree and M. Mudasira  Muskaan and S. Abdul Saleha and B. Shiva kumar and K. Mohammad Issaq},
        title = {Analytical method development and validation of capecitabine in bulk dosage form by using uv spectrophotometry},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {4},
        pages = {1009-1022},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=184175},
        abstract = {A robust UV-visible spectroscopic method was developed and validated for the quantification of Capecitabine in bulk dosage form. The method is based on the drug's ultraviolet absorbance, optimized at a maximum wavelength of 325 nm. Using ethanol as the solvent, the method demonstrated linearity within the concentration range of 5–25 µg/ml, adhering to Beer's law. Validation of the method encompassed parameters such as accuracy, precision, specificity, and linearity, ensuring its reliability for pharmaceutical analysis. Recovery studies further affirmed the accuracy and applicability of the technique for routine quality control. The simplicity, rapidity, and cost-effectiveness of this UV-visible spectroscopic method make it an efficient tool for analyzing Capecitabine in bulk pharmaceutical formulations},
        keywords = {Capecitabine, Beer's law, Uv spectroscopy},
        month = {September},
        }

Cite This Article

Akhila, B., & Keerthi, P., & sree, N. N., & Muskaan, M. M. ., & Saleha, S. A., & kumar, B. S., & Issaq, K. M. (2025). Analytical method development and validation of capecitabine in bulk dosage form by using uv spectrophotometry. International Journal of Innovative Research in Technology (IJIRT), 12(4), 1009–1022.

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