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@article{184352,
        author = {Om S. Pandekar and Sanskruti S. Pandekar and Vaishnavi A. Patil and Tanaya M. Patil and Vaishnavi V. Patil and Mr. Rohan R. Vakhariya and Dr. Indrayani S. Bandgar},
        title = {Advances in RNA Therapeutics: Mechanistic Basis and Therapeutic Strategies},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {4},
        pages = {1076-1083},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=184352},
        abstract = {The term "non-druggable" refers to a protein that cannot be targeted pharmacologically; recently, significant efforts have been made to convert these proteins into targets that are reachable or "druggable." Pharmacologically targeting these difficult proteins has emerged as a major challenge in modern drug development, necessitating the innovation and development of new technologies. The idea of using RNA-targeting therapeutics as a platform to reach unreachable targets is very appealing. Antisense oligonucleotides, nucleic acids or aptamers, RNA interference therapeutics, microRNA, and synthetic RNA are examples of RNA-targeting therapeutics. The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto “undruggable” proteins, transcripts, and genes, thus potentially broadening the therapeutic targets. Several RNA-based medications have been approved for clinical use, while others are still under investigation or in preclinical trials. Various techniques have been explored to promote RNA intracellular trafficking and metabolic stability, despite significant challenges in developing RNA-based therapeutics. In this review, the mechanisms of action, challenges, solutions, and clinical application of RNA-based therapeutics have been comprehensively summarized.},
        keywords = {Drug development, RNA-targeting, medications, metabolic stability.},
        month = {September},
        }