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@article{185514,
        author = {Dr. Rupak Roy and Bhavya Saraf and Shreosee Ghosh and Pranati Das},
        title = {Bioactive Natural Products as Multitargeted Anticancer Agents: Mechanisms, Preclinical Evidence, and Translational Challenges},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {3988-3997},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185514},
        abstract = {Cancer remains one of the leading causes of morbidity and mortality worldwide, demanding continuous innovation in treatment strategies. Natural compounds derived from plants, marine organisms, microbes, and animals offer a diverse arsenal of bioactive molecules with potent anticancer properties. These agents act through multiple mechanisms, including induction of apoptosis, cell cycle arrest, inhibition of angiogenesis and metastasis, epigenetic modulation, and immunomodulation. This review examines the therapeutic potential of natural compounds, including curcumin, fucoidan, taccalonolides, honokiol, and others, and discusses their molecular targets and clinical relevance. Furthermore, we discuss their synergistic effects with conventional therapies, the outcomes of key in vivo and clinical trials, and the challenges of translating these agents into clinical applications. Emerging technologies such as nanocarrier-based delivery systems and synthetic biology offer promising solutions to overcome bioavailability and production issues. By integrating traditional pharmacognosy with modern biomedical approaches, natural compounds are poised to become a cornerstone of future oncological therapeutics.},
        keywords = {natural compounds; anticancer agents; apoptosis; marine bioactives, phytochemicals; immunomodulation; chemotherapy synergy; drug discovery},
        month = {October},
        }