Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{185654,
        author = {Pavithra S and Dr. G Lambodaran},
        title = {Regenerative prosthodontic - A review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {2354-2358},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185654},
        abstract = {Prosthodontics, as a branch of dentistry, has traditionally focused on restoring missing teeth and oral tissues with artificial substitutes such as removable dentures, crowns, fixed bridges, and dental implants. These methods have improved oral function and aesthetics for millions of patients worldwide. However, they remain mechanical solutions that cannot restore the living tissues themselves. For example, a dental implant may replace the crown and root of a tooth, but it does not bring back the natural periodontal ligament or pulp vitality.
In recent years, the convergence of stem cell biology, biomaterials research, and tissue engineering has given rise to an innovative discipline known as regenerative prosthodontics. This new approach seeks to biologically restore lost oral structures — including bone, periodontal ligament, gingiva, dental pulp, and even entire teeth. By using stem cells, scaffolds, and growth factors, regenerative prosthodontics aims to create living tissue replacements that integrate seamlessly with the patient’s oral cavity.
The purpose of this review is to highlight the foundations, applications, advantages, challenges, and future prospects of regenerative prosthodontics. Special emphasis is placed on explaining these concepts in a simplified, student-friendly manner. Current applications include alveolar ridge regeneration, peri-implant soft tissue engineering, pulp–dentin complex regeneration, and experimental approaches to whole-tooth bioengineering. Advantages such as improved biological integration and long-term stability are contrasted with limitations like high cost, ethical concerns, and lack of extensive human clinical trials.
Looking forward, technologies such as 3D and 4D bioprinting, exosome-based therapies, induced pluripotent stem cells (iPSCs), and artificial intelligence are likely to play a central role in advancing this field. Ultimately, regenerative prosthodontics has the potential to transform dentistry from a practice of replacing lost tissues with artificial substitutes into one of biologically regenerating natural tissues.},
        keywords = {Regenerative prosthodontics, stem cells, tissue engineering, biomaterials, scaffolds, growth factors, alveolar regeneration, pulp–dentin complex, bioengineering, and 3D bioprinting.},
        month = {October},
        }