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@article{186056,
        author = {Dr. Avvinish Annant Narine and Prof. Gopesh Mangal},
        title = {A Panchkarma Approach in the Management of Sarvanga Vatavyadhi (MND–Amyotrophic Lateral Sclerosis): A Clinical Case Report},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {128-133},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186056},
        abstract = {Background: Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by degeneration of upper and lower motor neurons, resulting in progressive muscle weakness and loss of motor control. Conventional management is primarily supportive, with pharmacological interventions offering only modest benefit. Ayurveda, through the Panchkarma approach, provides a holistic therapeutic model aimed at alleviating symptoms, improving functional ability and enhancing quality of life. Case Presentation: A 56-year-old female with early-onset ALS presented with progressive weakness of both upper limbs, initially involving the right index finger 2.5 years earlier. Over time, tremors developed during weight lifting, accompanied by upper-body and low-back weakness, bilateral knee instability and difficulty in standing, walking and prolonged sitting. She had no comorbidities such as diabetes or hypertension. Neurological examination revealed decreased motor activity and a nerve conduction study showed a non-recordable F-wave in the right median nerve, confirming motor neuron dysfunction. Intervention: The patient underwent a structured Panchkarma protocol comprising Yapana Basti and Shashtika Shali Pinda Swedana for 16 days, Nasya Karma with Trisati Prasarini Taila for 14 days, followed by Shamana therapy for 15 days to consolidate therapeutic gains. Outcomes: Following intervention, clinical improvement was noted in muscle strength, postural stability and mobility, with higher ALSFRS-R, Norris and WHOQOL-BREF scores. Subjective relief from fatigue and improved daily functioning were reported, without adverse events. Conclusion: This case demonstrates that integrative Ayurvedic therapies can provide meaningful symptomatic relief and functional improvement in a patient of ALS. While encouraging, single-patient outcomes require validation through larger clinical trials to establish efficacy.},
        keywords = {Amyotrophic Lateral Sclerosis, Ayurveda, Panchkarma, Yapana Basti, Shashtika Shali Pinda Swedana, Nasya Karma.},
        month = {November},
        }