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@article{186116,
        author = {N V Sree Lalitha and Md Quamruz Zafar},
        title = {Functional Ingredient Mapping in PCOS Formulations: Hormonal Excess},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {53-59},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186116},
        abstract = {Polycystic Ovary Syndrome is a complicated hormonal imbalance that causes symptoms such as the production of excessive male hormones, irregular or no ovulation, and metabolic changes, even in non-obesity women. One of the most important pathophysiological charac-teristics is the overproduction of androgens, which changes the GH/IGF-1 axis and makes the body inca-pable of regulating ovulation and hormones. Clinical evidence indicates that an androgen decrease may be able to restore the hormonal axis deficiency thus the onset of ovulation would be possible. This article repre-sents the characterization of functional ingredients that simulate the endocrine-restoring effects of surgical pro-cedures such as ovarian wedge resection (OWR), which are promising to lower the release of the androgens (testosterone, androstenedione) and to enhance GH/IGF-1 actions. We are creating a nutraceutical so-lution based on the presence of functional bioactive compounds with anti-androgenic, and insulin-sensitizing properties. Myo-inositol, D-chiro-inositol, spearmint extract, omega-3 fatty acids, licorice root, and vitamin D are some of the naturally occurring compounds that can modulate the hypothalamic-pituitary-ovarian axis, lower androgen secretion, and improve insulin signalling. Individually, these agents have the potential to stimulate dopaminergic activity, promote somatotropic function, and thus, become a less invasive and more sustainable option than surgical in-tervention.},
        keywords = {Androgen excess, insulin resistance, nutraceuticals, PCOS, reproductive health},
        month = {October},
        }