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@article{186472,
        author = {Ansari Sana Parveen and Abhishek Das},
        title = {Insilico vaccine designing for bovine tuberculosis along with the vector construction targeting the RV1410c antigenic protein},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {12},
        number = {no},
        pages = {198-205},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186472},
        abstract = {Bovine tuberculosis (bTB), caused by Mycobacterium bovis, poses a significant threat to livestock health and presents zoonotic risks to humans. This stud investigates the protein Rv1410c, a putative ABC transporter implicated in the pathogen's survival and virulence. We analyzed Rv1410c's structural and functional properties using a comprehensive bioinformatics approach, employing sequence alignment, homology modeling, and molecular docking studies. Our findings reveal the conservation of Rv1410c across mycobacterial species, suggesting its fundamental role in bacterial physiology. We constructed protein-protein interaction networks to elucidate its involvement in critical cellular pathways and performed epitope mapping and antigenicity prediction, identifying Rv1410c as a promising candidate for vaccine development. Additionally, molecular docking studies highlighted several small molecules with high binding affinity as potential inhibitors of Rv1410c. This research enhances our understanding of Rv1410c's role in M. bovis pathogenesis and lays the groundwork for future experimental validation of in silico vaccine candidates. The strategic framework provided by this study underscores the importance of bioinformatics in modern vaccine development, offering new avenues for combating bovine tuberculosis and improving animal health.},
        keywords = {bioinformatics Bovine tuberculosis, in silico vaccine design, immunogenicity Rv1410c.},
        month = {},
        }