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@article{188924,
        author = {Mr. Harshad Nanabhau Nakade and Dr. Sunil D. Kolhe and Mr.Anail M. Dhaygude},
        title = {Recent Progress in Thiazolidinone Research: Green Synthesis, Hybrid Molecules, and Therapeutic Prospects},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {4190-4200},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188924},
        abstract = {Thiazolidinones constitute a privileged heterocyclic scaffold in medicinal chemistry due to their structural flexibility, electrophilic C-2 carbonyl group, and ease of functional modification at the C-5 position. Over recent years, rational derivatization through arylidene substitution, heterocyclic fusion, and incorporation of electron-donating or electron-withdrawing groups has markedly improved their biological potency, selectivity, and multi-target activity. These derivatives exhibit significant anticancer, antimicrobial, antitubercular, anti-inflammatory, antioxidant, and antidiabetic effects, acting through mechanisms such as modulation of apoptotic pathways, redox regulation, inflammatory enzyme inhibition, and metabolic receptor activation. Advances in sustainable synthetic strategies including green chemistry approaches, microwave-assisted one-pot reactions, and computationally supported design have accelerated the development of structurally diverse analogues. Parallel increases in patent filings highlight growing industrial interest, particularly in oncology and infectious disease applications. However, key challenges persist, notably in optimizing pharmacokinetic behavior, establishing comprehensive in vivo efficacy, and elucidating detailed molecular mechanisms. Future efforts should focus on multi-target hybrid derivatives, eco-friendly synthesis, nanocarrier-based delivery systems, and robust early stage ADME/Tox evaluation. Overall, thiazolidinones remain a versatile and highly promising scaffold for next-generation therapeutic development.},
        keywords = {Thiazolidinone derivatives, Multi target agents, Computational drug design and Drug development.},
        month = {December},
        }