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@article{188969,
        author = {G CHANDRA SAI KUMAR and Dr. P. Narayanaraju},
        title = {Development of Dapagliflozin Effervescent Floating Tablets},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {4307-4315},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188969},
        abstract = {Dapagliflozin is a highly potent and reversible sodium-glucose cotransporter-2 (SGLT2) drug now being used for the treatment of Type 2 diabete (TD2M) that acts selectively on sodium-glucose cotransporter-2. Dapagliflozin can be used as mono-therapy or combination therapy as glucose-lowering agents for the treatment of T2DM. Either, it is taken once daily orally for its use as monotherapy in patients who are experiencing metformin intolerance, or in combination with hypo-glycaemic agents such as metformin, sulfonyl ureas, and insulin. The present investigation concerns the development and evaluation of effervescent floating tablets of Dapagliflozin which, after oral administration, are designed to prolong the gastric residence time and increase drug bioavailability. A floating drug delivery system (FDDS) was developed using gas-forming agent like sodium bicarbonate and polymers like Pullulan gum, polyethylene oxide and hydroxypropyl methylcellulose (HPMC). The combination of hydrophillic and hydrophobic polymer such as ethyl cellulose was studied. The tablets were prepared by direct compression and evaluated in terms of their physical characteristics, in vitro release, buoyancy, buoyancy lag-time, swelling and erosion index. The formulation was subjected to various kinetic release investigations and it was found that the mechanism of drug release was predominantly diffusion with a minor contribution from polymeric relaxation. DSC and FTIR study of pure Dapagliflozin and formulations showed that there is no drug-polymer interaction. Finally, the tablet formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.},
        keywords = {Dapagliflozin, GRDDS (Gastro Retentive Drug Delivery System), Floating Tablets.},
        month = {December},
        }