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@article{189288,
        author = {DHANASHREE KIRAN CHIVTE and VAISHNAVI KIRAN CHIVTE},
        title = {OVERCOMING BIOLOGICAL BARRIERS WITH STEALTH LIPOSOMES: TRENDS IN DESIGN AND CLINICAL PERFORMANCE},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {5159-5163},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189288},
        abstract = {Liposomes are phospholipid-based vesicular systems widely used for drug delivery due to their biocompatibility, ability to encapsulate both hydrophilic and lipophilic compounds, and flexibility in structural modification. However, conventional liposomes face major limitations, including rapid clearance by the mononuclear phagocyte system (MPS), instability in plasma, and limited circulation time. The development of polyethylene glycol (PEG)-coated “stealth liposomes” represents a major advancement in nanocarrier design, allowing prolonged blood circulation, reduced opsonization, and improved passive tumor targeting through the enhanced permeability and retention (EPR) effect. This review summarizes the fundamental concepts of liposomes, PEGylation strategies, physicochemical properties influencing stability, characterization techniques, advantages of stealth liposomes, and their cancer and non-cancer biomedical applications. Special emphasis is placed on clinical relevance, pharmacokinetic improvements, and targeted delivery approaches.},
        keywords = {Liposomes, PEGylation, Stealth liposomes, Drug delivery, Nanomedicine, Targeted therapy, EPR effect.},
        month = {December},
        }