Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{189596,
        author = {Shivani Prakash Bhanuse and Amanpreet Kaur Dumda Palaya},
        title = {REVIEW ON SOLUBILITY ENHANCEMENT STRATEGIES FOR ATORVASTATIN CALCIUM},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {7100-7105},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189596},
        abstract = {The ability of a drug to dissolve in water, or its solubility, is crucial for it to reach the bloodstream in the right amount and produce its intended effect. Many new drugs are lipophilic, meaning they do not dissolve well in water, which often limits their effectiveness and market potential. Improving solubility is therefore a major challenge in developing new drug formulations. Various strategies, such as reducing particle size, modifying chemical structure, adjusting pH, making solid dispersions, forming complexes, using co-solvents, and employing micelles or hydrotropes, have been explored to address this problem.
Atorvastatin calcium is a widely used drug for lowering cholesterol and reducing the risk of heart disease. It belongs to BCS Class II, which means it is easily absorbed by the body but has poor water solubility. This low solubility limits how fast it dissolves and how well it is absorbed, making formulation more difficult. This review looks at the properties that make atorvastatin poorly soluble and examines different ways to improve it. These include reducing particle size, creating solid dispersions, using lipid-based systems like SEDDS and SNEDDS, forming co-crystals, making nanosuspensions, and adjusting pH or salts, sometimes combining multiple approaches.
The review also discusses solubility enhancement strategies used for similar For BCS Class II drugs, both traditional and advanced techniques such as cyclodextrin complexation, nanosizing, lipid-based formulations, and the use of surfactants are discussed in terms of how they work, along with their advantages and limitations. Newer techniques, including amorphous formulations, nanocrystals, and supercritical fluid methods, are also highlighted. The review wraps up by sharing practical ideas and future possibilities for improving how atorvastatin calcium is absorbed when taken orally.},
        keywords = {Solubility; Bioavailability; Atorvastatin calcium; BCS Class II; Solid dispersion; Nanosuspension; Lipid-based delivery; SEDDS; Cyclodextrin; Co-crystal},
        month = {December},
        }