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@article{189691,
        author = {Galaba Yamini Padmasri and Dr. B. Thangabalan and Shohida Khatun and Subhadeep Pratihar and Sapna Pathak and Pusunuri Pranitha and Chiruvolulanka Dharmik Ram Teja and Varshitha Asukolla},
        title = {Microneedles as a Novel Approach for Transdermal Drug Administration},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {7425-7432},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189691},
        abstract = {Transdermal drug delivery (TDDS) has become as a promising alternative to conventional administration routes due to its ability to bypass the first-pass metabolism, reduce systemic side effects, and increases patient compliance. However, the skin’s outermost barrier, the stratum corneum, limits the passive permeation of most therapeutic molecules, mainly hydrophilic drugs and macromolecules. Microneedle (MN) technology has become significant attention as an innovative strategy to overcome these barriers by creating transient microchannels that enable efficient and minimally lethal drug transport. There are various types of microneedles including solid, coated, dissolving, hollow, and hydrogel-forming have been developed to support the delivery of a wide range of therapeutic agents such as small molecules, peptides, proteins, vaccines, and nucleic acids. Their flexibility extends beyond drug administration to applications in diagnostics, biosensing, dermatological treatments, ocular delivery, and gene therapy. Compared to the other traditional methods, microneedles offer more advantages to the patients such as painless application, reduced infection risk, higher stability for sensitive biologics, and suitability for self-administration. Despite notable progress, challenges remain in terms of large-scale fabrication, mechanical strength, drug-loading capacity, and variability in skin physiology. Continued advancements in materials science, microfabrication, and smart delivery technologies are expected to further enhance microneedle performance and broaden their clinical applicability. Overall, microneedle-based transdermal systems represent a transformative platform capable of improving therapeutic outcomes, expanding drug delivery possibilities, and contributing significantly to the future of patient-centered biomedical innovation.},
        keywords = {Stratum Corneum, Microneedle, Hydrogel, Hyaluronic acid, carboxymethyl cellulose,Polymers},
        month = {December},
        }