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@article{189728,
        author = {Mansi  sarambale and Priyanka hajare},
        title = {Advances in Sustained Release Drug Delivery: Focus on Matrix Systems},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {170-178},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189728},
        abstract = {Sustained release drug delivery systems have emerged as an essential approach in modern pharmaceutical therapy to improve therapeutic efficacy, patient compliance, and safety. Among the various controlled release strategies, oral sustained release matrix tablets are widely preferred due to their simplicity of formulation, cost-effectiveness, and regulatory acceptance. This review comprehensively discusses the principles, mechanisms, and applications of sustained release drug delivery systems with particular emphasis on matrix-based formulations. Various drug release mechanisms, including diffusion-controlled, dissolution-controlled, ion-exchange, osmotic pressure–based, pH-independent, and altered-density systems, are systematically described. The classification of matrix tablets based on polymer type, porosity, and retardant materials is also highlighted. Additionally, the role of polymers, formulation components, and drug release kinetics governing matrix systems is elaborated. Overall, this review provides a detailed understanding of sustained release matrix drug delivery systems and underscores their significance in achieving prolonged therapeutic action, minimizing plasma drug fluctuations, and enhancing patient adherence to therapy.},
        keywords = {Sustained release; Controlled drug delivery; Matrix tablets; Diffusion-controlled release; Dissolution-controlled release; Osmotic drug delivery; Ion-exchange systems; pH-independent formulations; Altered-density formulation; Hydrophilic polymers; Hydrophobic polymers; Biodegradable matrices; Drug bioavailability; Patient compliance},
        month = {January},
        }