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@article{190160,
        author = {Sharmila Chaudhary and Shweta Gupta and Shiv Dev Singh},
        title = {A Comprehensive Review on the Synthesis of Mannich Base Compounds as Potential Anti-diabetic Agents},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {870-876},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190160},
        abstract = {This review explores the antidiabetic potential of Mannich base-modified heterocyclic compounds. These compounds were tested for inhibitory activity against alpha-amylase, a critical enzyme in glucose metabolism, and shown considerable suppression, indicating their potential for glycemic management. Furthermore, benzothiazole-oxadiazole Mannich base conjugates displayed significant antidiabetic effectiveness in an alloxan-induced diabetic rat model, which was confirmed by their inhibition of lipase, alpha-glucosidase, and acetylcholinesterase.
The synthesized compounds were structurally characterized using infrared spectroscopy, proton nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, elemental analysis, and mass spectrometry, confirming their identification and demonstrating their promise as antidiabetic possibilities. These findings indicate that Mannich base-modified heterocycles present a promising multi-target approach for diabetes management and medication development.},
        keywords = {Mannich base, Anti-diabetic activity, heterocyclic-containing compound.},
        month = {January},
        }