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@article{190212,
        author = {Drx. Mohan Shyam and Simmy Kardam and Neha Rathore},
        title = {Formulation Approaches for Buccal Delivery of Exemestane in Breast Cancer Therapy},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {1602-1609},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190212},
        abstract = {The most widespread clinical subtype of breast cancer is hormone receptor-positive tumor, which remains an important health issue in the world. Exemestane is a third-generation steroidal aromatase inhibitor commonly used to suppress estrogen levels in women who are post-menopausal. Its oral bioavailability is however variable and it is subject to high hepatic first-pass metabolism, and low water solubility limits its efficacy as a therapy. These downs compel the necessity of alternative delivery systems. Buccal drug delivery devices have been found to deliver a non-invasive method that does not depend on the initial tissue passages, diminishes gastrointestinal loss, and provides a more predictable systemic triumph of the drug. The formulation strategies used in distributing exemestane buccally that are the focus of the current research include mucoadhesive pills, films, patches, gels, and a nanotechnology-based system such as polymeric and lipid nanoparticles. We discuss the techniques that enhance the process of buccal absorption, such as increased solubility, increased absorption through the mucosal, degradation resistance, and controlled drug delivery. Evaluation metrics, safety concerns, issues related to formulation, and prospects, including quality-by-design and hybrid mucoadhesive-nanocarrier are also highlighted. Another possible strategy in long-term cancer therapy of breast cancers is buccal intake, which would help enhance treatment efficiency and treatment adherence.},
        keywords = {},
        month = {January},
        }