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@article{190296,
        author = {Sakshi Shivaji Bodkhe and Amanpreet Kaur Dumda Palaya},
        title = {SOLUBILITY ENHANCEMENT STRATEGIES OF WARFARIN},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {1372-1379},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190296},
        abstract = {The solubility of a drug plays a very important role in how well it works in the body. Many drugs do not dissolve easily in water, and this can reduce the amount of drug absorbed after administration. According Biopharmaceutical Classification System (BCS), Class II drugs have good ability to pass through biological membranes but poor water solubility. Because of this, they often show slow or incomplete absorption, which can lead to variable therapeutic effects and formulation challenges.
Improving the solubility of BCS Class II drugs is therefore essential to ensure better absorption. and consistent clinical performance. This review discusses various methods used to enhance the solubility of these drugs, including both traditional and modern formulation approaches. Common techniques such as solid dispersions, cyclodextrin complex formation, reduction of particle size, lipid-based drug delivery systems, and the use of surfactants are explained in simple terms, focusing on how they work, along with their advantages and limitations. In addition, newer and advanced strategies-such as amorphous drug formulations, nanocrystal technology, and supercritical fluid processing-are also described, highlighting recent progress in pharmaceutical formulation science aimed at improving drug solubility and effectiveness.},
        keywords = {Bioavailability, solubility, nanosuspension, solid dispersion, lipophilicity},
        month = {January},
        }