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@article{190728,
        author = {Anavadhya. P},
        title = {Space Microbiology and Human Physiology in Extraterrestrial Environments: Insights from Spaceflight and Simulations},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {3053-3062},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190728},
        abstract = {Space microbiology and human physiology research in extraterrestrial environments provide critical insights into the adaptive mechanisms of microorganisms and human systems under microgravity, cosmic radiation, and confined habitats. Microorganism’s exhibit altered growth, biofilm formation, virulence, metabolic pathways, and genetic regulation, which can influence spacecraft hygiene, crew health, and the efficiency of bioregenerative life-support systems. Similarly, human cells experience synergistic stress effects, including DNA damage, oxidative stress, immune dysregulation, mitochondrial dysfunction, and altered signaling pathways, leading to systemic consequences such as bone loss, cardiovascular remodeling, neuro-ocular impairments, and apoptosis modulation. Research approaches integrate ground-based simulations, spaceflight experiments, and multi-omics analyses to elucidate cellular, molecular, and physiological adaptations, enabling the development of effective countermeasures. Databases such as NASA GeneLab consolidate omics datasets, fostering predictive modeling, translational research, and personalized health strategies for long-duration missions. Beyond astronaut safety, these studies advance biotechnology, regenerative medicine, and astrobiology by elucidating microbial resilience, adaptation mechanisms, and potential life in extreme extraterrestrial environments. The integration of simulation models, real-time spaceflight studies, and omics technologies positions space biology as a vital discipline for sustaining human exploration and addressing broader biomedical challenges on Earth.},
        keywords = {Microgravity, Space Microbiology, Space Radiation, Bioregenerative Life Support.},
        month = {January},
        }