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@article{190843,
        author = {P. UDAYA CHANDRIKA and KURVA BHAVANI and P. SOBITHA RANI and AV. KISHORE BABU},
        title = {EVALUATION OF ANTIINFLAMATORY ACTIVITY OF BUDDLEJA DAVIDII},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {5203-5214},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190843},
        abstract = {Objective: The present study aimed to evaluate the anti-inflammatory activity of Buddleja davidii extract using various acute and chronic inflammation models in rats.
Methods: The anti-inflammatory potential of Buddleja davidii was assessed at two doses (400 mg/kg and 600 mg/kg) using carrageenan, histamine, dextran, serotonin, and formaldehyde-induced paw oedema models, as well as the cotton pellet-induced granuloma model. Diclofenac sodium (10 mg/kg) served as the standard drug. Biochemical parameters, including total protein, albumin, acid phosphatase (ACP), and alkaline phosphatase (ALP), were also measured.
Results: Buddleja davidii significantly reduced paw edema in all models, indicating both early- and late-phase anti-inflammatory activity. The higher dose (600 mg/kg) consistently showed greater efficacy, often comparable to Diclofenac. The extract also demonstrated a marked reduction in granuloma weight in the cotton pellet model, indicating activity against chronic inflammation. Biochemical analysis revealed improved protein levels and reduced ALP activity, suggesting hepatoprotective potential.
Conclusion: The findings suggest that Buddleja davidii possesses broad-spectrum anti-inflammatory properties, acting through multiple mechanisms. These results support its traditional medicinal use and highlight its potential as a natural therapeutic agent for treating both acute and chronic inflammatory conditions.},
        keywords = {Buddleja davidii, anti-inflammatory, ALP activity, Paw edema.},
        month = {January},
        }