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@article{190929,
        author = {Aarti Ramdas Mekale and Rutuja Rangnath Khandade and Dr Sachin Hangargekar and Madhav Marotirav Kabade and Rayan Sadik Sayyad and Dr Vishveshwar Dharashive},
        title = {A comprehensive review on antiseptic gel},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {5355-5363},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190929},
        abstract = {Herbal antiseptic gels have gained increasing attention as natural alternatives to conventional synthetic antiseptics due to rising concerns about skin irritation, microbiome disruption, and long-term safety associated with repeated use of chemical disinfectants. These gels are formulated using medicinal plant extracts and essential oils rich in bioactive phytochemicals such as flavonoids, phenolics, tannins, alkaloids, terpenoids, and saponins, which collectively provide broad-spectrum antimicrobial, anti-inflammatory, antioxidant, and wound-healing effects. Commonly used botanicals include Aloe vera, Azadirachta indica (neem), Curcuma longa (turmeric), tea tree oil, garlic, ginger, lemongrass, and guava leaves, each contributing unique mechanisms of action against bacteria, fungi, and certain viruses.Herbal antiseptic gels offer several advantages over synthetic formulations, including improved skin compatibility, reduced irritation, lowelr risk of antimicrobial resistance due to multi-target activity, and environmental friendliness. Their gel-based nature, achieved using natural or synthetic polymers such as aloe gel, xanthan gum, carbopol, or HPMC, ensures ease of application, good spreadability, and user acceptability. These formulations are classified based on active herbal ingredients, extraction methods, antimicrobial mechanisms, gelling agents, and therapeutic applications, ranging from routine hand hygiene and wound care to acne management and cosmetic use.Understanding skin anatomy and physiology is essential for evaluating the safety and effectiveness of these gels, as most act on the epidermal surface while supporting barrier integrity and wound healing. Preparation methods involve careful extraction, formulation, pH adjustment, and evaluation to ensure stability and efficacy. Overall, literature evidence supports herbal antiseptic gels as effective, safe, and versatile topical agents, though challenges such as standardization, stability, and large-scale clinical validation remain for future research.},
        keywords = {Antiseptic gel, Topical antiseptic formulations, Herbal antiseptic gel, Synthetic antiseptic gel, Hand sanitizer gels, Antimicrobial gel formulations, Topical antimicrobial agents},
        month = {January},
        }