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@article{193317,
        author = {Girish S Paldhe and Mitesh N Bhosale and Sandeep R Nikam},
        title = {Probiotics and Hydrogels in Wound Healing: A Synergistic Approach to Advanced Wound Care},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {75-89},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193317},
        abstract = {Chronic wounds remain a significant challenge in modern medicine due to persistent infections, prolonged inflammation, and the rise of antibiotic-resistant bacteria. Traditional wound treatments often fail to address these root causes effectively. Recent advancements highlight the promising role of probiotic-based hydrogels, which combine the moisture-retaining and protective properties of hydrogels with the antimicrobial and immunomodulatory benefits of probiotics. Hydrogels create a conducive environment for wound healing by maintaining moisture, promoting cell migration, and facilitating tissue regeneration. When infused with probiotics, such as Lactobacillus and Bifidobacterium strains, these hydrogels can modulate the wound microbiome, outcompete harmful bacteria, reduce biofilm formation, and stimulate the immune system. This review explores the synergistic mechanisms of action between probiotics and hydrogels, including their ability to deliver therapeutic agents, accelerate wound closure, and promote angiogenesis. Additionally, this article addresses the challenges of formulating probiotic-infused hydrogels and the potential for future clinical applications, including personalized wound care solutions and multifunctional hydrogel systems. By integrating probiotics and hydrogels, this approach offers a novel and effective solution for treating chronic wounds, potentially reducing infection risks and the overuse of antibiotics.},
        keywords = {Probiotics, Hydrogels, Wound healing, Skin microbiome, Infection control, Tissue regeneration, Biomedical applications},
        month = {March},
        }