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@article{193617,
        author = {Suraj Vinayak Kannar and Prof Amol G Jadhao},
        title = {Formulation and Evaluation of Sustained-Release Tablets of Metformin Hydrochloride},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {2084-2088},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193617},
        abstract = {Metformin Hydrochloride is a first-line oral antidiabetic drug used in the management of Type 2 Diabetes Mellitus; however, its short half-life and frequent dosing are associated with poor patient compliance and gastrointestinal side effects. The present study aimed to formulate and evaluate sustained-release tablets of Metformin Hydrochloride to achieve prolonged drug release and improved therapeutic efficacy. Sustained-release tablets were prepared using hydrophilic and hydrophobic polymers, including Hydroxypropyl Methylcellulose, Ethyl Cellulose, and Eudragit, by direct compression and/or wet granulation techniques. The formulations were evaluated for physicochemical properties, tablet characteristics, and in-vitro dissolution behavior. Drug release data were analyzed using various kinetic models to determine the release mechanism. The optimized formulation demonstrated minimal burst release and sustained drug release up to 12 hours, following diffusion-controlled non-Fickian transport. The study confirms that polymer-based sustained-release tablets of Metformin Hydrochloride can effectively enhance patient compliance and therapeutic outcomes.},
        keywords = {Metformin Hydrochloride; Sustained-release tablets; Matrix system; HPMC; Drug release kinetics},
        month = {March},
        }