Intestinal Toxicity of Glyphosate in Clarias gariepinus: A Biochemical and Histological Assessment

  • Unique Paper ID: 193805
  • Volume: 12
  • Issue: 10
  • PageNo: 3098-3107
  • Abstract:
  • This study evaluated the biochemical and histopathological effects of glyphosate on the intestine of the African catfish, Clarias gariepinus. Fish were exposed to 5 mg/L and 10 mg/L glyphosate for 10 days. Results showed a significant, dose-dependent decrease in intestinal protein and carbohydrate levels, along with sex-specific changes in the pyloric intestine somatic index. Histological examination revealed severe structural damage, including villi degeneration, epithelial disruption, goblet cell alterations, and nuclear pyknosis, with greater severity at higher concentrations. These findings indicate that glyphosate causes marked metabolic and intestinal toxicity in C. gariepinus, highlighting its potential ecological risk to freshwater organisms.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{193805,
        author = {Jitendra N. Rathor and Vaibhav R. Zade},
        title = {Intestinal Toxicity of Glyphosate in Clarias gariepinus: A Biochemical and Histological Assessment},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {3098-3107},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193805},
        abstract = {This study evaluated the biochemical and histopathological effects of glyphosate on the intestine of the African catfish, Clarias gariepinus. Fish were exposed to 5 mg/L and 10 mg/L glyphosate for 10 days. Results showed a significant, dose-dependent decrease in intestinal protein and carbohydrate levels, along with sex-specific changes in the pyloric intestine somatic index. Histological examination revealed severe structural damage, including villi degeneration, epithelial disruption, goblet cell alterations, and nuclear pyknosis, with greater severity at higher concentrations. These findings indicate that glyphosate causes marked metabolic and intestinal toxicity in C. gariepinus, highlighting its potential ecological risk to freshwater organisms.},
        keywords = {Intestine, Histopathology, Biochemical alterations, Herbicide toxicity},
        month = {March},
        }

Cite This Article

Rathor, J. N., & Zade, V. R. (2026). Intestinal Toxicity of Glyphosate in Clarias gariepinus: A Biochemical and Histological Assessment. International Journal of Innovative Research in Technology (IJIRT), 12(10), 3098–3107.

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