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@article{193819,
        author = {Vd Pooja Sainath Chandapure and Dr Milind Chatrabhuji},
        title = {Pharmaceutical Preparation and Analytical Evaluation of Rasa Sindura},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {2187-2197},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193819},
        abstract = {Rasa Sindura is a classical Kupipakwa Rasayana formulation extensively described in Ayurvedic Rasashastra literature for its potent therapeutic efficacy and rejuvenative properties. It is primarily prepared from purified mercury (Shuddha Parada) and purified sulphur (Shuddha Gandhaka), which undergo a series of classical pharmaceutical processes including Shodhana (purification), Kajjali preparation, and Kupipakwa (controlled heating in a sealed glass bottle). These processes are designed not only to detoxify the raw materials but also to transform them into a stable, bioassimilable, and therapeutically active compound. During the Kupipakwa procedure, mercury and sulphur undergo complex physicochemical transformations leading to the formation of a sublimated red crystalline compound predominantly composed of mercuric sulphide (HgS). Rasa Sindura has been traditionally indicated in various disease conditions such as chronic fevers, respiratory disorders, digestive ailments, and general debility owing to its Rasayana, Yogavahi, and potent catalytic properties. Despite its widespread therapeutic application, the presence of mercury in the formulation has raised concerns regarding safety and toxicity. However, classical Rasashastra emphasizes that proper purification and pharmaceutical processing render mercury therapeutically safe and effective. Therefore, scientific validation and standardization of the preparation process are essential. In recent decades, modern analytical techniques have been increasingly applied to study traditional Ayurvedic mineral formulations. Analytical evaluation of Rasa Sindura using advanced techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), atomic absorption spectroscopy (AAS), Fourier transform infrared spectroscopy (FTIR), and particle size analysis provides valuable insights into its chemical composition, crystalline structure, morphology, and elemental profile. These studies confirm that the final product predominantly consists of stable crystalline mercuric sulphide with nano- to micro-sized particles, which may contribute to improved bioavailability and therapeutic activity. The present article reviews the classical pharmaceutical preparation of Rasa Sindura along with its analytical characterization using modern scientific tools. The study highlights the importance of standardization and pharmaceutico-analytical evaluation in ensuring the quality, safety, and therapeutic reliability of Rasashastra formulations.},
        keywords = {Rasa Sindura, Kupipakwa Rasayana, Rasashastra, Parada, Gandhaka, Kajjali, Pharmaceutical standardization, Analytical evaluation},
        month = {March},
        }