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@article{194109,
        author = {S.G.Raman and Dr. R.Sundhararaja and Subalakshmi.M and Ramya.N and Rafiya Thul Safran Jainuva.S and Bala Venkatesh.M and Mohamed Jarvise.A},
        title = {NOVEL POTENTIAL INHIBITORS OF THE HEPATITIS C VIRUS NS3|4A PROTEASE USING INTEGRATED COMPUTATIONAL APPROACHES},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {2714-2726},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=194109},
        abstract = {Hepatitis C is a liver disease caused by HCV. Hepatitis C can range from a mild illness lasting a few weeks to a serious, long-term illness.  The hepatitis C virus (HCV) spreads through contact with blood that has the virus in it. Newer antiviral medicines are the treatment of choice for most people with the ongoing, called chronic, hepatitis C infection. Additionally, options with fewer side effects and simpler dosing would improve patient adherence and outcomes.
In this research, molecular docking studies was carried out on NS3/4A protease (a serine hydrolase enzyme) and unknown protein as anti-hepatitis C virus agents against HCV target. Also, prediction of toxicity of the drugs were done.
Molecular docking is a computational technique widely used in drug discovery and bioinformatics to predict how a small molecule (ligand) interacts with a target protein (receptor). Docking is a method which predicts the preferred orientation of the one ligand when bound in an active site to form a stable complex. 
The chemical information of the respective compounds was taken from PUBCHEM. PubChem is a free database used to find chemical structures, properties, and biological activities, aiding drug discovery and research. Biovia discovery studio was used to construct two-dimensional and three-dimensional diagrams of docked Hepatis C Virus protein-ligand complexes. MZDOCK is used for docking. It a computational tool used for predicting protein–protein interactions through rigid-body docking, helping researchers’ model how two proteins bind.},
        keywords = {Hepatis C Virus, molecular docking, Toxicity, MZDOCK.},
        month = {March},
        }