Analytical Techniques for Drug Stability Evaluation: A Review on UV Spectroscopy, HPLC for Forced Degradation Studies in Pharmaceutical Products

  • Unique Paper ID: 194727
  • Volume: 12
  • Issue: 10
  • PageNo: 5507-5541
  • Abstract:
  • Drug stability evaluation, which ensures the efficacy, safety, and quality of pharmaceutical products over their shelf life, is an essential part of pharmaceutical development. Analytical techniques are crucial for monitoring drug stability and identifying potential degradation pathways. This study focuses on the use of ultraviolet (UV) spectroscopy and high-performance liquid chromatography (HPLC) as essential analytical tools in pharmaceutical quality assurance (QA) and quality control (QC). Due to its affordability, speed, and convenience of use, UV spectroscopy is a widely used technique for quantitatively identifying pharmaceutical compounds. In contrast, HPLC offers superior sensitivity, selectivity, and accuracy for the detection and separation of pharmaceuticals and the byproducts of their concept and importance of forced degradation studies are also discussed as an essential component in the development of stability-indicating analytical techniques. These studies subject medicinal compounds to stress conditions such hydrolysis, oxidation, photolysis, and heat degradation in order to understand degradation mechanisms and identify breakdown routes. Furthermore, the significance of QA and QC in ensuring method dependability, regulatory compliance, and product quality is highlighted. This paper compiles current analytical methods, methodological concerns, and regulatory perspectives on medication stability testing. All things considered, the combination of UV spectroscopy, HPLC, and forced degradation investigations provides a comprehensive basis for the development of trustworthy stability-indicating methods in pharmaceutical analysis

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{194727,
        author = {V.DEEPANANDHAM and Dr.K.Y.KAVITHA and Dr.A.SARAVANAKUMAR and Dr.P.PARTHIBAN and M.C.KAVIN KUMAR and C.DEEPA and R.KAMALI and J.NIRANJANA},
        title = {Analytical Techniques for Drug Stability Evaluation: A Review on UV Spectroscopy, HPLC for Forced Degradation Studies in Pharmaceutical Products},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {5507-5541},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=194727},
        abstract = {Drug stability evaluation, which ensures the efficacy, safety, and quality of pharmaceutical products over their shelf life, is an essential part of pharmaceutical development. Analytical techniques are crucial for monitoring drug stability and identifying potential degradation pathways. This study focuses on the use of ultraviolet (UV) spectroscopy and high-performance liquid chromatography (HPLC) as essential analytical tools in pharmaceutical quality assurance (QA) and quality control (QC). Due to its affordability, speed, and convenience of use, UV spectroscopy is a widely used technique for quantitatively identifying pharmaceutical compounds. In contrast, HPLC offers superior sensitivity, selectivity, and accuracy for the detection and separation of pharmaceuticals and the byproducts of their concept and importance of forced degradation studies are also discussed as an essential component in the development of stability-indicating analytical techniques. These studies subject medicinal compounds to stress conditions such hydrolysis, oxidation, photolysis, and heat degradation in order to understand degradation mechanisms and identify breakdown routes. Furthermore, the significance of QA and QC in ensuring method dependability, regulatory compliance, and product quality is highlighted. This paper compiles current analytical methods, methodological concerns, and regulatory perspectives on medication stability testing. All things considered, the combination of UV spectroscopy, HPLC, and forced degradation investigations provides a comprehensive basis for the development of trustworthy stability-indicating methods in pharmaceutical analysis},
        keywords = {UV Spectroscopy, HPLC, Forced Degradation Studies, Drug Stability, Pharmaceutical QA/QC, Stability-Indicating Methods.},
        month = {March},
        }

Cite This Article

V.DEEPANANDHAM, , & Dr.K.Y.KAVITHA, , & Dr.A.SARAVANAKUMAR, , & Dr.P.PARTHIBAN, , & KUMAR, M., & C.DEEPA, , & R.KAMALI, , & J.NIRANJANA, (2026). Analytical Techniques for Drug Stability Evaluation: A Review on UV Spectroscopy, HPLC for Forced Degradation Studies in Pharmaceutical Products. International Journal of Innovative Research in Technology (IJIRT), 12(10), 5507–5541.

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