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@article{195083,
        author = {SANTHIYA KANNAN and SALINI VISWANATHAN and SAKTHISWARUBA MANIMUTHU and DR. DEEPSHIKA SARAVANAN and DR.VIJAY.V.K. and DR.MARIA SUBASH AARON MUTHURAJ},
        title = {A SILENT PUPPETEER - PORPHYROMONAS GINGIVALIS AND HOST IMMUNE DYSREGULATION},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {6973-6977},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195083},
        abstract = {Periodontitis is a chronic inflammatory disease characterized by progressive destruction of the supporting structures of the teeth. Its pathogenesis involves complex interactions between microbial biofilms and host immune responses. Among the periodontal pathogens, Porphyromonas gingivalis has emerged as a keystone pathogen capable of disrupting immune homeostasis and promoting microbial dysbiosis. This Gram-negative anaerobic bacterium expresses several virulence factors, including gingipains, fimbriae, lipopolysaccharide, outer membrane vesicles and capsular polysaccharides, which facilitate immune evasion and modulation of host inflammatory pathways. By interfering with both innate and adaptive immune responses, P. gingivalis promotes persistent inflammation and creates a favorable environment for the proliferation of pathogenic microbial communities. The resulting dysbiosis contributes to connective tissue degradation and alveolar bone resorption, ultimately leading to periodontal tissue destruction. Furthermore, increasing evidence suggests that P. gingivalis may contribute to systemic inflammatory conditions such as cardiovascular disease, diabetes mellitus and neurodegenerative disorders. Understanding the mechanisms by which this pathogen manipulates host immunity provides important insights into periodontal disease progression and may support the development of novel therapeutic strategies aimed at host modulation and microbial control.},
        keywords = {Porphyromonas gingivalis, host immune dysregulation, virulence factors, keystone pathogen},
        month = {March},
        }