Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{195548,
        author = {Mr. Vivek Pravinbhai kotadiya},
        title = {A Review on Crystal Engineering of APIs at Microscopic Scale for Enhancement of Bioavailability & Solubility},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {11},
        pages = {1171-1183},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195548},
        abstract = {The crystal engineering of Active Pharmaceutical Ingredients (APIs) at the microscopic scale to enhance their bioavailability and solubility. Many promising new medicines fail because they do not dissolve easily, leading to poor absorption and low bioavailability. Crystal engineering offers a "smart way to fix this problem" by rationally reshaping the solid form of the medicine to achieve desired properties. The primary methods discussed for solubility enhancement include: co-crystallization, solid dispersions, and amorphization. For example, co-crystals, which are distinct solid forms held together by non-covalent interactions, can improve a drug's solubility, dissolution rate, and stability without changing its chemical structure. Advanced characterization techniques such as Powder X-Ray Diffraction (PXRD), Scanning Electron Microscopy (SEM), and Differential Scanning Calorimetry (DSC) are crucial for analyzing these engineered crystal forms. The ongoing challenge is achieving reliable design and long-term stability in these new forms, especially in the pursuit of enhanced drug performance.},
        keywords = {Crystal Engineering, Enhancement of Bioavailability and Solubility, Intermolecular Interaction, Co crystal},
        month = {April},
        }