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@article{195705,
        author = {Dr. Madhuri S. Hingankar and Dr. Megha R. Solanke},
        title = {Advances In Genome Sequencing, Gene Expression Analysis, And Functional Genomics: A Short Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {no},
        pages = {120-122},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195705},
        abstract = {Molecular biology and genomics have transformed the understanding of gene structure, regulation, and function by enabling genome-wide analysis of DNA, RNA, and regulatory mechanisms. This review summarizes major advances in genome sequencing, transcriptome-based gene expression profiling, and functional genomics approaches that connect genotype to phenotype. Next-generation sequencing (NGS) and long-read sequencing have improved genome assembly, variant discovery, and the detection of structural changes associated with disease. Transcriptomics, including RNA sequencing (RNA-seq), single-cell transcriptomics, and epigenomic profiling, reveals dynamic regulation of gene expression across tissues, cell types, and disease states. Functional genomics platforms such as CRISPR-based genome editing and genome-scale screening support experimental validation of gene function and regulatory networks. Applications include improved diagnosis of rare genetic disorders, molecular stratification of cancers, pharmacogenomic prediction of drug response, and insights into evolution and population diversity. Although genomics continues to accelerate precision medicine, challenges remain in variant interpretation, computational demands, ethical oversight, and equitable clinical access.},
        keywords = {next-generation sequencing; RNA-seq; functional genomics; CRISPR; personalized medicine},
        month = {March},
        }