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@article{195724,
        author = {PREETHIVARTHANA and POONGODI and DR. DEEPSHIKA SARAVANAN and DR.VAISHNAVI},
        title = {Neutrophil Extracellular Traps in Periodontitis Mechanisms, Pathogenesis and Clinical Implications – A Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {11},
        pages = {741-745},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195724},
        abstract = {Periodontitis is a chronic inflammatory condition that leads to gradual destruction of the periodontal ligament and alveolar bone due to interactions between microbial biofilms and the host immune response. Neutrophils are key immune cells in periodontal defense and help maintain oral health by eliminating pathogens through processes such as phagocytosis, degranulation, and the production of reactive oxygen species. In addition to these mechanisms, neutrophils can release neutrophil extracellular traps (NETs), which are networks of chromatin fibers combined with antimicrobial proteins that capture and neutralize microorganisms. This process, known as NETosis, plays an important role in innate immunity by limiting the spread of periodontal pathogens. However, excessive or dysregulated NET formation may contribute to tissue injury and prolonged inflammation in periodontal tissues. Components of NETs, including histones and neutrophil elastase, can activate inflammatory pathways and promote alveolar bone resorption. Increased levels of NET-related biomarkers have been detected in gingival crevicular fluid and periodontal tissues of affected patients, suggesting their involvement in disease progression and potential diagnostic value.},
        keywords = {Neutrophil extracellular traps, NETosis, Periodontitis, Neutrophil-mediated immunity, Periodontal inflammation, Alveolar bone loss, Gingival crevicular fluid biomarkers},
        month = {April},
        }