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@article{195863,
        author = {Syed Yunis Bukhari and Anuj Kumar and Sakshi Dhiman and Dokala Naresh and Pardeep Kumar},
        title = {Role of the Gut Microbiome in Gastric Cancer: A Systematic Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {11},
        pages = {4157-4159},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195863},
        abstract = {Background: Gastric cancer is one of the leading causes of cancer-related mortality worldwide and continues to pose a major health burden in India, particularly in the Kashmir region. Although Helicobacter pylori infection is a well-established etiological factor, eradication of H. pylori alone does not completely eliminate gastric cancer risk, suggesting the involvement of additional microbial factors.
Materials and Methods: A systematic review of published literature was conducted using PubMed, Scopus, and Embase databases. Human studies evaluating gut or gastric microbiome alterations in gastric cancer and precancerous lesions were included. Relevant data were extracted and analyzed qualitatively.
Aims and Objectives:
1.	To study the role of gut and gastric microbiome in gastric cancer
2.	To assess microbiome alterations across different stages of gastric carcinogenesis
3.	To evaluate the clinical relevance of microbiome dysbiosis
Results: Thirty-two studies were included in the review. Gastric cancer patients consistently demonstrated reduced microbial diversity with enrichment of pathogenic bacteria such as Fusobacterium, Prevotella, Streptococcus, and Lactobacillus. Dysbiosis was observed from chronic gastritis to advanced carcinoma.
Conclusion: Gut and gastric microbiome dysbiosis plays a significant role in gastric carcinogenesis. Recognition of microbiome alterations may aid in early diagnosis and preventive strategies, particularly in high-risk regions like Jammu and Kashmir.},
        keywords = {Gastric cancer, Gut microbiome, Gastric microbiota, Dysbiosis.},
        month = {April},
        }