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@article{195917,
        author = {SHAILENDRA SANJAY SURYAWANSHI and VRUSHALI VIJAY PATIL and RAJ DEELIP MAYANNA and TANAY ANIKET BHINGURDE and M. S. PALLED SHAILENDRA SANJAY SURYAWANSHI},
        title = {FLAVONOSOMES: A SYSTEMATIC REVIEW ON FORMULATION DEVELOPMENT, ANALYTICAL CHARACTERIZATION AND THERAPEUTIC PERFORMANCE},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {11},
        pages = {1514-1522},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195917},
        abstract = {Flavonoids are natural polyphenolic compounds with diverse pharmacological properties, including antioxidant, anti-inflammatory, anticancer, cardioprotective, and antimicrobial effects. However, their therapeutic application is limited by poor aqueous solubility, low chemical stability, rapid metabolism, and minimal oral bioavailability. Flavonosomes, phospholipid-based vesicular systems, have emerged as a promising strategy to overcome these limitations. These complexes enhance flavonoid stability, improve membrane permeability, and provide controlled release, resulting in superior bioavailability and therapeutic performance compared to free flavonoids. This review consolidates current knowledge on the formulation development, pre-formulation considerations, analytical characterization, and evaluation parameters of flavonosomes, with particular emphasis on Indian research contributions. Preparation methods such as solvent evaporation, thin film hydration, anti-solvent precipitation, and supercritical fluid-assisted techniques are discussed, highlighting their influence on particle size, entrapment efficiency, and stability. Analytical tools, including spectroscopic, thermal, crystallographic, and chromatographic techniques, are employed to confirm flavonoid–phospholipid interactions and ensure quality control. Preclinical studies demonstrate that flavonosomes enhance in vitro and in vivo antioxidant, anti-inflammatory, anticancer, and antimicrobial activities, outperforming unformulated flavonoids. Despite their potential, challenges remain in reproducibility, scale-up, analytical standardization, stability, and the lack of clinical evidence. Future perspectives focus on targeted delivery, stimuli-responsive systems, green formulation strategies, and advanced chemometric analyses to facilitate clinical translation. Collectively, flavonosomes offer a versatile platform to optimize flavonoid delivery, bridging the gap between preclinical efficacy and therapeutic application},
        keywords = {Analytical Characterization, Bioavailability, Flavonoids, Flavonosomes, Drug Delivery.},
        month = {April},
        }