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@article{200194,
        author = {Roshini K V and Gouri Vijayan and Fidha Fathima M M and Rameesa T S and Nafeesathul Fidha},
        title = {Evaluation of Neuroprotective Effect of a Novel Compound in a Zebrafish Model of Parkinson’s Disease – A Review Article},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {12},
        pages = {438-442},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=200194},
        abstract = {Parkinson's disease (PD) is a progressive, chronic neurodegenerative illness defined by the early death of a large number of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and a widespread accumulation of alpha synuclein (aSyn), an intracellular protein. A reduction in dopamine levels in the basal ganglia is responsible for producing both motor and non-motor symptoms. Given their similarities with human brain physiology and anatomy, zebrafish have emerged as an important animal model system for studying Parkinson’s disease. Like the mammalian brain, the zebrafish brain contains all three primary brain divisions (forebrain, midbrain, hindbrain), along with a diencephalon and telencephalon; furthermore, the primary neurotransmitter functions of the brain are largely equivalent to those found in mammals. This review outlines the various zebrafish-based models of Parkinson’s disease, including those generated via the administration of neurotoxins such as MPTP, 6-OHDA, rotenone, and paraquat. Different behavioral assays like locomotor tracking, the novel tank diving test, and startle response are employed to assess both motor impairment and neurobehavioral modifications, while molecular analyses (e.g., RT-qPCR) are performed for the purpose of investigating changes in gene expression associated with neurodegeneration, oxidative stress, and apoptosis. Zebrafish models provide an inexpensive and efficient means of screening neuroprotective agents and understanding the mechanisms of the development of pathology within the disease process. The present review outlines the value of employing zebrafish in neuropharmacological research and their potential application in developing new treatment approaches for Parkinson’s disease.},
        keywords = {},
        month = {May},
        }