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@article{203147,
        author = {Krushna punjaram bangar and Ass. Prof. Vidya Raosaheb Kale},
        title = {FORMULATION AND EVALUATION OF ANTIMALARIA POWDER SACHET BY USING CINCHONA BARK},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {12},
        pages = {12148-12157},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=203147},
        abstract = {Malaria remains one of the most significant global health challenges, particularly in tropical and subtropical regions, where morbidity and mortality rates are high. Conventional antimalarial therapies, though effective, are often associated with drug resistance, adverse effects, and limited accessibility in rural populations. In this context, herbal formulations offer a promising alternative due to their affordability, safety, and cultural acceptance. Cinchona bark, a well-established natural source of quinoline alkaloids such as quinine, has historically played a pivotal role in malaria treatment and continues to be relevant in modern pharmacotherapy.
The present study aims to formulate and evaluate a standardized antimalarial powder sachet (15 g) containing Cinchona bark powder as the principal active ingredient. The formulation strategy emphasizes accurate dosing, patient compliance, and ease of administration, particularly in resource-limited settings. The sachet dosage form was selected to ensure portability, stability, and suitability for paediatric and adult populations. The methodology involves pharmacogenetic characterization of Cinchona bark, including macroscopic, microscopic, and phytochemical screening to confirm authenticity and quality. The powdered bark will be processed under controlled conditions to preserve alkaloid content, followed by blending with suitable excipients to enhance flow properties, palatability, and stability. Sachets will be prepared in uniform 15 g doses and subjected to evaluation parameters such as organoleptic properties, weight uniformity, moisture content, flow characteristics, alkaloid assay (quinine content), microbial load, and stability studies under accelerated conditions.
The expected outcome of this research is a lab-validated herbal sachet formulation with reproducible quality, acceptable physicochemical parameters, and confirmed antimalarial activity through in vitro or literature-supported pharmacological evidence. This study not only reinforces the therapeutic potential of Cinchona bark but also contributes to the development of herbal dosage forms tailored for endemic regions. The findings may serve as a foundation for further clinical evaluation and large-scale production, thereby supporting the integration of traditional pharmacognosy with modern pharmaceutical technology in combating malaria.},
        keywords = {Cinchona bark, antimalarial, powder sachet, quinine, herbal formulation, malaria therapy, evaluation parameters.},
        month = {May},
        }