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@article{204508,
        author = {Sakshi Prabhakar Dhutmal and Dr. N. G. Patre and Dr. Sayyed Ali},
        title = {To formulate and evaluate Repaglinide Control Release Tablet},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {3644-3653},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204508},
        abstract = {The present study aimed to formulate and evaluate controlled release tablets of Repaglinide for prolonged drug delivery in the treatment of type 2 diabetes mellitus. Controlled release tablets were prepared by the wet granulation method using hydroxypropyl methylcellulose (HPMC) and Eudragit RS100 as release-retarding polymers. Preformulation studies confirmed the acceptable physicochemical properties of Repaglinide. The prepared formulations were evaluated for pre-compression and post-compression parameters, including angle of repose, bulk density, tapped density, hardness, friability, weight variation, and drug content. All formulations showed satisfactory flow properties, mechanical strength, and uniform drug distribution. In vitro dissolution studies demonstrated sustained drug release over 12 hours. Among all formulations, F8 and F12 exhibited optimized drug release profiles with prolonged release characteristics. The study concluded that controlled release matrix tablets of Repaglinide can be successfully developed to improve therapeutic efficacy and patient compliance in diabetes management.},
        keywords = {Repaglinide, Controlled Release Tablets, Matrix Tablets, Sustained Drug Release, HPMC, Eudragit RS100, Wet Granulation, Diabetes Mellitus.},
        month = {June},
        }