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@article{204530,
        author = {Dr. Mangesh A. Bhutkar and Payal V. Lokhande and Sakshi D. Kuchekar},
        title = {Development and Optimization of Sertaconazole Nitrate Emulgel for Topical Antifungal Therapy},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {2535-2540},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204530},
        abstract = {To improve the delivery and release qualities, this work studies formulation and assessment of a topical emulgel formulation holding Sertaconazole nitrate, an antifungal drug of the imidazole class. Synthetic polymer and surfactants were the building blocks of the emulgel recipe. Ingredients including glycerin, propylene glycol, isopropyl myristate, tween 80, carbopol 940, and methyl paraben are also present. Nine distinct formulations (F1-F9) were created to investigate the effects of concentration on physiochemical properties and medication release. The in-vitro drug diffusion, viscosity, spreadability, pH, and physical appearance of the formulations have all been assessed. These pH levels, which fall within the permitted range for topical treatment, ranged from 6.00 to 6.25. Because of its role as a gelling agent, carbopol 940 raises the formulation's viscosity with increasing concentration. As the amount of carbopol 940 increases, the amount of increase in viscosity makes the spreadability of the prepared emulgel decrease. The content of the drug in all formulations was found to be consistent ranging from 98.45% to 101.35%. Experiments on drug diffusion in vitro demonstrated that formulation F7 released 95.09% of the medication in 8 hours overall. The outcomes show that antifungal drugs like sertaconazole nitrate can be more effectively distributed using the emulgel technology. F7 showed superior drug dispersion, stability, and physical qualities compared to the other formulations, suggesting it may be a viable substitute for the standard topical antifungal medicines that were examined.},
        keywords = {Sertaconazole nitrate, Topical drug delivery, Emulgel, Antifungal therapy, Factorial design.},
        month = {June},
        }