Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{204871,
        author = {Sulugoori Swetha and A.Aparna and Y.Shravan Kumar and Ch.Ramya},
        title = {ENHANCING ORAL BIOAVAILABILITY OF FELODIPINE USING SOLID SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEMS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {4770-4777},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204871},
        abstract = {Developing a drug product with improved solubility and bioavailability is a challenge for poorly water-soluble drugs such as Felodipine. The aim of the present work was to develop a solid self-micro emulsifying drug delivery system (SMEDDS) of Felodipine to improve its solubility and dissolution rate. Solubility of Felodipine was determined in various oils, surfactants, and co-surfactants, and the micro emulsion region was identified by constructing a pseudo ternary phase diagram using the water titration method. Stable SMEDDS was prepared using a combination of Tween 20 and PEG 600 (2:1) with clove oil (7.5% v/v), and liquid SMEDDS was subsequently converted into solid SMEDDS (S-SMEDDS) by adsorption onto Aerosil 200 as a solid carrier. The S-SMEDDS was evaluated for micromeritic properties and in-vitro drug release, with results showing a cumulative drug release of 99% within 90 minutes, a particle size of 78.3 nm, a zeta potential of -17.4 mV, and a polydispersibility index of 0.27. These findings conclude that S-SMEDDS is a promising solid dosage form that significantly improves the solubility, dissolution rate, and oral bioavailability of Felodipine.},
        keywords = {S-SMEDDS, Pseudo ternary phase diagram, bioavailability, dissolution rate.},
        month = {June},
        }