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@article{205169,
        author = {Dr. Fatemeh Moazzamipeiro and Pro. Dr. Nisha Gupta and Prof. Dr. Gopesh Mangal},
        title = {From Agni to the microbiota-gut-brain axis: a critical translational framework for Grahani Roga, irritable bowel syndrome, and Priyangvadi Basti},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {5364-5384},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205169},
        abstract = {irritable bowel syndrome (IBS) is a heterogeneous disorder of gut-brain interaction characterized by recurrent abdominal pain or discomfort and altered bowel habits without structural disease sufficient to explain the full symptom complex. Its pathophysiology may include variable combinations of motility disturbance, visceral hypersensitivity, altered central processing, epithelial barrier dysfunction, mucosal immune activation, dietary fermentation, microbial ecological disturbance, metabolite variation, autonomic dysregulation, and psychosocial influences. Ayurveda describes Grahani Roga as a chronic digestive regulatory disorder centered on impaired Agni, defective retention and progression of food, incomplete transformation, Ama formation, and Vata-mediated instability. This critical narrative review examines classical descriptions from the Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya alongside contemporary evidence on IBS, microbiota, intestinal interface biology, neuroimmune signaling, post-infective change, psychophysiological regulation, and the microbiota-gut-brain axis. A five-layer translational model is proposed, linking transformation, substrate ecology, digestive interface integrity, coordinated movement, and central-affective regulation while preserving essential boundaries: Grahani Roga is not identical to IBS; Ama is not synonymous with dysbiosis; Pittadhara Kala is not equivalent to intestinal mucosa; and Vata cannot be reduced to neural control. Priyangvadi Basti is interpreted as a classical Grahi and Vata-regulating intervention whose clinical efficacy and biomedical mechanisms require direct testing. The framework is intended to support reproducible Ayurvedic phenotyping, standardized intervention protocols, validated patient-centered outcomes, and prespecified mechanistic research rather than retrospective claims of equivalence.},
        keywords = {Grahani Roga; Agni; Ama; irritable bowel syndrome; gut-brain axis; microbiota; Priyangvadi Basti},
        month = {June},
        }