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@article{205210,
        author = {Dr. Fatemeh Moazzamipeiro and Prof. Dr. Nisha Gupta and Prof. Dr. Gopesh Mangal},
        title = {Classical Ayurveda Pathophysiology of Grahanidosha and its Correlation with Irritable Bowel Syndrome (IBS)},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {5619-5632},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205210},
        abstract = {Grahanidoshais a well-described gastrointestinal disorder in Ayurvedic literature that arises primarily from impairment of Agni (digestive fire). In classical Ayurvedic physiology, Grahani is considered the organ responsible for retaining ingested food until proper digestion occurs and releasing it into the lower gastrointestinal tract following complete metabolic transformation. When Agni becomes weakened, particularly in the form of Mandagni, digestion becomes defective, leading to the formation of Ama, a pathological metabolic by-product that disrupts digestive physiology and contributes to the development of Grahani Roga. Classical texts describe Grahanidoshaas a chronic digestive disorder characterized by irregular bowel habits, indigestion, abdominal discomfort, heaviness of the body, fatigue, and passage of improperly digested food particles. Contemporary gastroenterology describes several functional gastrointestinal disorders with similar clinical manifestations, among which Irritable Bowel Syndrome (IBS) shows the closest resemblance. IBS is characterized by recurrent abdominal discomfort associated with altered bowel habits, including diarrhea, constipation, or alternating bowel patterns, and affects approximately 10–15% of the global population. The present conceptual review aims to critically analyze the Ayurvedic understanding of Grahanidoshawith reference to classical descriptions of Agni, Nidana, Purvarupa, Rupa, Samprapti, and Chikitsa Siddhanta, and to correlate these concepts with contemporary knowledge of IBS pathophysiology. Classical Ayurvedic texts including Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, and Madhava Nidana were examined along with modern biomedical literature addressing functional gastrointestinal disorders. The analysis highlights conceptual parallels between Ayurvedic descriptions of Mandagni, Ama formation, Dosha imbalance, and Srotodushti and modern mechanisms including altered intestinal motility, gut microbiota dysbiosis, visceral hypersensitivity, and gut–brain axis dysregulation. Understanding Grahanidoshathrough both classical Ayurvedic principles and contemporary biomedical perspectives may provide valuable insights for developing integrative approaches to the management of chronic gastrointestinal disorders.},
        keywords = {Agni, Ayurveda, Grahani Roga, Irritable Bowel Syndrome, Malabsorption Syndromes.},
        month = {June},
        }